HIV-1 with HBV-associated Q151M substitution in RT becomes highly susceptible to entecavir: structural insights into HBV-RT inhibition by entecavir
نویسندگان
چکیده
منابع مشابه
Resistance patterns and response to entecavir intensification among HIV-HBV-coinfected adults with persistent HBV viremia.
combined with Truvada (emtricitabine/ tenofovir). However, there is very limited data on the efficacy of NVP + Kivexa, which seems to be a promising HAART combination for several reasons: very low cost; limited metabolic and lipid disturbances, and low pill burden (3 pills daily now but will reduce to 2 when the new once-daily extended-release NVP formulation becomes available). Provided that a...
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BACKGROUND/AIMS Cryoglobulinemic vasculitis remains an uncommon complication of hepatitis B virus infection. METHODS We report the case of a 40-years old female Chinese patient with chronic hepatitis B developing cryoglobulinemic vasculitis with multiple organ involvement (liver, kidney, and skin) coupled with weakness, arthralgias, haemolytic anaemia, and autoimmune thyroiditis. She received...
متن کاملRenal safety of tenofovir and/or entecavir in patients with chronic HBV monoinfection
BACKGROUND Tenofovir disoproxil fumarate (TDF) and entecavir (ETV) are recommended as the first-line therapy for chronic hepatitis B (CHB) due to their genetic barrier to resistance and effectiveness of virological suppression. TDF and ETV may cause renal toxicity through various mechanisms such as renal tubular injury, apoptosis, and mitochondrial toxicity. The aims of the current review were ...
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Infection with the hepatitis B virus (HBV) can result in chronic hepatitis B (CHB) in many patients. Patients with CHB require regular screening and monitoring to facilitate disease surveillance and to determine if/when treatment is indicated. The current goal of CHB treatment is sustained viral suppression with the aim of reducing or preventing hepatic injury and disease progression. Effective...
متن کاملStructure of the HIV-1 reverse transcriptase Q151M mutant: insights into the inhibitor resistance of HIV-1 reverse transcriptase and the structure of the nucleotide-binding pocket of Hepatitis B virus polymerase
Hepatitis B virus polymerase (HBV Pol) is an important target for anti-HBV drug development; however, its low solubility and stability in vitro has hindered detailed structural studies. Certain nucleotide reverse transcriptase (RT) inhibitors (NRTIs) such as tenofovir and lamivudine can inhibit both HBV Pol and Human immunodeficiency virus 1 (HIV-1) RT, leading to speculation on structural and ...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2018
ISSN: 2045-2322
DOI: 10.1038/s41598-018-19602-9